Evolutionary Molecular Engineering as Thought and Technology

Computational Molecular Engineering as an Emerging Technology in Process Engineering

The present level of development of molecular force field methods is assessed from the point of view of simulation-based engineering, outlining the immediate perspective for further development and highlighting the newly emerging discipline of Computational Molecular Engineering (CME) which makes basic research in soft matter physics fruitful for industrial applications. Within the coming decad...

Creative Thought as a nonDarwinian Evolutionary Process

Selection theory requires multiple, distinct, simultaneously-actualized states. In cognition, each thought or cognitive state changes the ‘selection pressure’ against which the next is evaluated; they are not simultaneously selected amongst. Creative thought is more a matter of honing in a vague idea through redescribing successive iterations of it from different real or imagined perspectives; ...

Software Engineering as Technology Transfer

We propose, as a challenge to the software engineering research community, a new view of software engineering as technology transition. In this view, the role of software engineering is to take the initial results of theorists and harden these results to the point where they are ready to be used in fielded, commercial systems. Current techniques for software verification, while adequate for ser...

Molecular Beacon Technology for Tissue Engineering Applications

Introduction Detection of RNA in cells is routinely performed by in vitro methods such as RT-PCR and fluorescent in situ hybridization (FISH). RTPCR quantifies gene expression of a cell population. FISH requires fixation of cells, thus unable to give a true picture of mRNA localization. Molecular beacons (MBs) are antisense oligonucleotide stem-loop probes that fluoresce upon hybridization with...

Evolutionary Molecular Engineering to Efficiently Direct in vitro Protein Synthesis